BL02U1

Xitong Song, Qian Wang, Xiaoxi Zhu, Wenhan Fang, Xiaonan Liu, Chao Shi, Zhenzhan Chang, Huifeng Jiang, Binju Wang Unraveling the Catalytic Mechanism of Taxadiene-5α-hydroxylase from Crystallography and Computational Analyses. ACS Catalysis, 14(6), 3912-3925. (2024).

Zhi Su, Weizhen Zhang, Yu Shi, Tao Cui, Yongchang Xu, Runshi Yang, Man Huang, Chun Zhou, Huimin Zhang, Ting Lu, Jiuxin Qu, Zheng-Guo He, Jianhua Gan, Youjun Feng A bacterial methyltransferase that initiates biotin synthesis, an attractive anti-ESKAPE druggable pathway. Science Advances, 10(51), eadp3954.

Zihui Su, Chengqun Niu, Sicong Zhou, Guolyu Xu, Pingchuan Zhu, Qiang Fu, Yuelin Zhang, Zhenhua Ming Structural basis of chorismate isomerization by Arabidopsis ISOCHORISMATE SYNTHASE1. Plant Physiology, 196(2), 773-787. (2024).

Jian Sun, Xiangxiang Zhang, Liu Xue, Liang Cheng, Jing Zhang, Xin Chen, Zhirong Shen, Kang Li, Lai Wang, Chichi Huang, Jing Song Structural insights into the unique pH-responsive characteristics of the anti-TIGIT therapeutic antibody Ociperlimab. Structure, 32(5), 550-561.e555. (2024).

Guanghui Tang, Wei Wang, Chengjun Zhu, Huisi Huang, Peng Chen, Xuan Wang, Manyi Xu, Jie Sun, Chong-Jing Zhang, Qicai Xiao, Liqian Gao, Zhi-Min Zhang, Shao Q. Yao Global Reactivity Profiling of the Catalytic Lysine in Human Kinome for Covalent Inhibitor Development. Angewandte Chemie International Edition, 63(12), e202316394. (2024).

Yaqian Tang, Dan Wu, Yueying Zhang, Xuan Liu, Hui Chu, Qian Tan, Lixu Jiang, Shi Chen, Geng Wu, Lianrong Wang Molecular basis of the phosphorothioation-sensing antiphage defense system IscS–DndBCDE–DndI. Nucleic Acids Research, 52(22), 13594-13604. (2024).

John C. Tellis, BinQing Wei, Michael Siu, Le An, Grace Kayan Chan, Yong Chen, Xiangnan Du, Lewis Gazzard, Baihua Hu, James Kiefer, Satoko Kakiuchi-Kiyota, Michael Lainchbury, Jonathan L. Linehan, Xifeng Luo, Sushant Malhotra, Rohan Mendonca, Jodie Pang, Yinqing Ran, Vijay Sethuraman, Eileen Seward, Chris Sneeringer, Dian Su, Weiru Wang, Ping Wu, John G. Moffat, Timothy P. Heffron, Edna F. Choo, Bryan K. Chan Discovery of GNE-6893, a Potent, Selective, Orally Bioavailable Small Molecule Inhibitor of HPK1. ACS Medicinal Chemistry Letters, 15(9), 1606-1614. (2024).

Chantel N. Trost, Jing Yang, Bianca Garcia, Yurima Hidalgo-Reyes, Beatrice C. M. Fung, Jiuyu Wang, Wang-Ting Lu, Karen L. Maxwell, Yanli Wang, Alan R. Davidson An anti-CRISPR that pulls apart a CRISPR–Cas complex. Nature, 632(8024), 375-382. (2024).