BL02U1

Baoyu Zhao, Cai Yuan, Rui Li, Dan Qu, Mingdong Huang, Jacky Chi Ki Ngo Crystal Structures of Matriptase in Complex with Its Inhibitor Hepatocyte Growth Factor Activator Inhibitor-1*. Journal of Biological Chemistry, 288(16), 11155-11164. (2013).

Li-Hua Zhao, X. Edward Zhou, Zhong-Shan Wu, Wei Yi, Yong Xu, Suling Li, Ting-Hai Xu, Yue Liu, Run-Ze Chen, Amanda Kovach, Yangyong Kang, Li Hou, Yuanzheng He, Cen Xie, Wanling Song, Dafang Zhong, Yechun Xu, Yonghong Wang, Jiayang Li, Chenghai Zhang, Karsten Melcher, H. Eric Xu Crystal structures of two phytohormone signal-transducing α/β hydrolases: karrikin-signaling KAI2 and strigolactone-signaling DWARF14. Cell Research, 23(3), 436-439. (2013).

W. Zheng, X. Feng, L. Qiu, Z. Pan, R. Wang, S. Lin, D. Hou, L. Jin, Y. Li Identification of the antibiotic ionomycin as an unexpected peroxisome proliferator-activated receptor γ (PPARγ) ligand with a unique binding mode and effective glucose-lowering activity in a mouse model of diabetes. Diabetologia, 56(2), 401-411. (2013).

Xiaozhang Zheng, Kenneth W. Bair, Paul Bauer, Timm Baumeister, Krista K. Bowman, Alexandre J. Buckmelter, Maureen Caligiuri, Karl H. Clodfelter, Yezhen Feng, Bingsong Han, Yen-Ching Ho, Nikolai Kley, Hong Li, Xiaorong Liang, Bianca M. Liederer, Jian Lin, Justin Ly, Thomas O’Brien, Jason Oeh, Angela Oh, Dominic J. Reynolds, Deepak Sampath, Geeta Sharma, Nicholas Skelton, Chase C. Smith, Jarrod Tremayne, Leslie Wang, Weiru Wang, Zhongguo Wang, Hongxing Wu, Jiansheng Wu, Yang Xiao, Guangxing Yang, Po-wai Yuen, Mark Zak, Peter S. Dragovich Identification of amides derived from 1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT). Bioorganic & Medicinal Chemistry Letters, 23(20), 5488-5497. (2013).

Xiaozhang Zheng, Paul Bauer, Timm Baumeister, Alexandre J. Buckmelter, Maureen Caligiuri, Karl H. Clodfelter, Bingsong Han, Yen-Ching Ho, Nikolai Kley, Jian Lin, Dominic J. Reynolds, Geeta Sharma, Chase C. Smith, Zhongguo Wang, Peter S. Dragovich, Angela Oh, Weiru Wang, Mark Zak, Janet Gunzner-Toste, Guiling Zhao, Po-wai Yuen, Kenneth W. Bair Structure-Based Identification of Ureas as Novel Nicotinamide Phosphoribosyltransferase (Nampt) Inhibitors. Journal of Medicinal Chemistry, 56(12), 4921-4937. (2013).

Jian Zhu, Qiqi Yang, Dandan Dai, Qiang Huang X-ray Crystal Structure of Phosphodiesterase 2 in Complex with a Highly Selective, Nanomolar Inhibitor Reveals a Binding-Induced Pocket Important for Selectivity. Journal of the American Chemical Society, 135(32), 11708-11711. (2013).

Yuwei Zhu, Jianxin Dai, Tiancheng Zhang, Xu Li, Pengfei Fang, Huajing Wang, Yongliang Jiang, Xiaojie Yu, Tian Xia, Liwen Niu, Yajun Guo, Maikun Teng Structural Insights into the Neutralization Mechanism of Monoclonal Antibody 6C2 against Ricin*. Journal of Biological Chemistry, 288(35), 25165-25172. (2013).